Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Keep this and all drugs out of the reach of children.

Description:Interceptor Plus is a monthly, broad spectrum parasiticide used to prevent heartworm disease, as well as treat and control common intestinal parasites including roundworms, hookworms, whipworms and tapeworms. Interceptor Plus offers long-lasting protection in the convenience of a tasty, easy-to-administer chewable. The chewable tablets are chicken flavored, which is an added benefit for dogs suffering from beef allergies. Most dogs love the taste, and you can rest assured that your best friend will be protected against heartworms for a full month. Interceptor Plus requires a prescription from your veterinarian. It is available as a 6-pack, which provides six months of heartworm protection.

Uses:Interceptor Plus is used for the prevention of heartworm disease caused by Dirofilaria immitis, and for the treatment and control of adult roundworm (Toxocara canis, Toxascaris leonina), adult hookworm (Ancylostoma caninum), adult whipworm (Trichuris vulpis) and adult tapeworm (Taenia pisiformis, Echinococcus multilocularis and Echinococcus granulosus) infections in dogs and puppies over 6 weeks in age and weighing over 2 lbs.

Dosage: Interceptor Plus should be administered orally, once every month, at the minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime, and 2.28 mg/lb (5 mg/kg) praziquantel. For heartworm prevention, give once monthly for at least 6 months after exposure. Dogs weighing 2-8 lbs should be given one Interceptor Plus chewable tablet (Brown Box) monthly. Dogs weighing 8.1-25 lbs should be given one Interceptor Plus chewable tablet (Green Box) monthly. Dogs weighing 25.1-50 lbs should be given one Interceptor Plus chewable tablet (Yellow Box) monthly. Dogs weighing 50.1-100 lbs should be given one Interceptor Plus chewable tablet (Blue Box) monthly.

Administration:Administer one Interceptor Plus chewable once every month. Interceptor Plus may be offered by hand or broken into pieces and fed to dogs that normally swallow treats whole. Interceptor Plus chewables should be administered in a manner that encourages your dog to chew, rather than to swallow without chewing. Care should be taken to be sure that your dog consumes the complete dose. Observe your dog for a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

Place the treatment reminder stickers (included) on your calendar for each of the months following the date of the initial treatment to help prevent missing a dose.

Interceptor Plus contains the active ingredient milbemycin oxime to prevent heartworm disease caused by Dirofilaria immitis. It also contains praziquantel, which treats tapeworm infection. It also treats and controls roundworms, hookworms, whipworms.

Precautions: For use in dogs and puppies over 6 weeks of age and weighing more than 2 pounds only. Do not use in cats or in humans. Keep this and all drugs out of the reach of children. Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. The safety of Interceptor Plus has not been evaluated in dogs used for breeding or in lactating females.

Adverse Reactions: Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention.

Safety:In the event of an overdose: Contact your veterinarian immediately.

Two studies in heartworm-infected dogs were conducted which demonstrated mild, transient hypersensitivity reactions in treated dogs with high microfilaremia counts (see Precautions for reactions observed). Safety studies in pregnant dogs demonstrated that high doses (1.5 mg/kg = 3X) of milbemycin oxime given in an exaggerated dosing regimen (daily from mating through weaning), resulted in measurable concentrations of the drug in milk. Puppies nursing these females which received exaggerated dosing regimens demonstrated milbemycin-related effects. These effects were directly attributable to the exaggerated experimental dosing regimen. The product is normally intended for once-a-month administration only. Subsequent studies included using 3X daily from mating to one week before weaning and demonstrated no effects on the pregnant females or their litters. A second study where pregnant females were dosed once at 3X the monthly use rate either before, on the day of or shortly after whelping resulted in no effects on the puppies.

Some nursing puppies, at 2, 4, and 6 weeks of age, given greatly exaggerated oral milbemycin oxime doses (9.6 mg/kg = 19X) exhibited signs typified by tremors, vocalization and ataxia. These effects were all transient and puppies returned to normal within 24 to 48 hours. No effects were observed in puppies given the recommended dose of milbemycin oxime (0.5 mg/kg). This product has not been tested in dogs less than 1 kg weight.