INFORMATION FOR DOSING DOGS

Simparica is a monthly prescription chewable tablet for the control of fleas and ticks on dogs that starts working fast and remains effective all month long.

Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Keep this and all drugs out of the reach of children.

Uses:Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Simparica TRIO requires a prescription from your veterinarian.

Indications:Simparica is used for the treatment and prevention of heartworm disease, five types of ticks, fleas, roundworms and hookworms.

Dosage:Simparica TRIO is a flavored chewable tablet that is given by the mouth. It can be given with or without food. Follow your veterinarian's instructions exactly as directed. The recommended minimum dose is 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Dogs weighing 2.8-5.5 lbs should be given one 3 mg sarolaner, 0.06 mg moxidectin, and 12.5 mg pyrantel chewable tablet (Gold Box). Dogs weighing 5.6-11.0 lbs should be given one 6 mg sarolaner, 0.12 mg moxidectin, and 25 mg pyrantel chewable tablet (Purple Box). Dogs weighing 11.1-22.0 lbs should be given one 12 mg sarolaner, 0.24 mg moxidectin, and 50 mg pyrantel chewable tablet (Caramel Box). Dogs weighing 22.1-44.0 lbs should be given one 24 mg sarolaner, 0.48 mg moxidectin, and 100 mg pyrantel chewable tablet (Teal Box). Dogs weighing 44.1-88.0 should be given one 48 mg sarolaner, 0.96 mg moxidectin, and 200 mg pyrantel chewable tablet (Green Box). Dogs weighing 88.1-132.0 lbs should be given one 72 mg sarolaner, 1.44 mg moxidectin, and 300 mg pyrantel chewable tablet (Brown Box).

Administration:Give your dog one chewable monthly, with or without food. Follow your veterinarian's instructions exactly as directed. The recommended minimum dose is 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Observe your dog for a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

Place the treatment reminder stickers (included) on your calendar for each of the months following the date of the initial treatment to help prevent missing a dose.

Precautions: Sarolaner, one of the ingredients in Simparica TRIO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Prior to administration of Simparica TRIO, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica TRIO is not effective against adult D. immitis. The safe use of Simparica TRIO has not been evaluated in breeding, pregnant, or lactating dogs.

Safety:In the event of an overdose: Contact your veterinarian immediately.